• 2019-10
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  • br In summary problems with body image seemed to


    In summary, problems with body image seemed to persist long time post-RRM, regardless of previous breast AZD7687 cancer or not. A decline in ‘General health’ appeared over time, but no HRQoL dif-ferences were found at the long-term follow-up between women with and without cancer. The long-term results of this AZD7687 study might be of clinical importance for women considering RRM in order for them to make an informed decision.
    Funding sources
    This study received financial support from the Swedish Cancer Society, Swedish Research Council, Radiumhemmets for-skningsfonder, and Breast cancer patient organisation fund
    (Brostcancerfonden)€. It has been used for administrative costs for data collection, analysis, interpretation of the data, in the writing of the report, and in the decision to submit the article for publication.
    Conflict of interest statement
    None to declare.
    Ethical approval
    [6] Arver B, Isaksson K, Atterhem H, Baan A, Bergkvist L, Brandberg Y, et al. Bilateral prophylactic mastectomy in Swedish women at high risk of breast 
    [8] Unukovych D, Sandelin K, Liljegren A, Arver B, Wickman M, Johansson H, et al. Contralateral prophylactic mastectomy in breast cancer patients with a family history: a prospective 2-years follow-up study of health related quality of life, sexuality and body image. Eur J Cancer 2012;48:3150e6. 10.1016/j.ejca.2012.04.023.
    [10] Gahm J, Wickman M, Brandberg Y. Bilateral prophylactic mastectomy in women with inherited risk of breast cancer e prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years
    [13] Frost MH, Schaid DJ, Sellers TA, Slezak JM, Arnold PG, Woods JE, et al. Long-term satisfaction and psychological and social function following bilateral prophylactic mastectomy. Jama 2000;284:319e24.
    [18] Wickman M, Sandelin K, Arver B. Technical aspects and outcome after pro-phylactic mastectomy and immediate breast reconstruction in thirty consecutive high-risk patients. Plast Reconstr Surg 2003;111:1069e77. [19] Thomson HJ, Winters ZE, Brandberg Y, Didier F, Blazeby JM, Mills J. The early development phases of a European Organisation for Research and Treatment of Cancer (EORTC) module to assess patient reported outcomes (PROs) in women undergoing breast reconstruction. Eur J Cancer 2013;49:1018e26.
    [20] Winters ZE, Balta V, Thomson HJ, Brandberg Y, Oberguggenberger A, Sinove Y, et al. Phase III development of the european organization for research and treatment of cancer quality of life questionnaire module for women under-going breast reconstruction. Br J Surg 2014;101:371e82. 10.1002/bjs.9397.
    [25] Sullivan M, Karlsson J, Ware JEJ. The Swedish SF-36 Health Survey-I. Evalua-tion of data quality, scaling assumptions, reliability and construct validity across general populations in Sweden. Soc Sci Med 1995;41:1349e58.
    [29] Berbers J, Van Baardwijk A, Houben R, Heuts E, Smidt M, Keymeulen K, et al. “Reconstruction: before or after postmastectomy radiotherapy?” A systematic review of the literature. Eur J Cancer 2014;50:2752e62.
    Body mass index and hormone receptor status influence recurrence risk in HER-2 positive early breast cancer patients
    Luca Cantini, Mirco Pistelli, Filippo Merloni, Andrea Fontana, Ilaria Bertolini, Claudia De Angelis, Lucia Bastianelli, Arianna Della Mora, Alfredo Santinelli, Agnese Savini, Elena Maccaroni, Lucrezia Diodati, Alfredo Falcone, Rossana Berardi
    To appear in: Clinical Breast Cancer
    Please cite this article as: Cantini L, Pistelli M, Merloni F, Fontana A, Bertolini I, De Angelis C, Bastianelli L, Della Mora A, Santinelli A, Savini A, Maccaroni E, Diodati L, Falcone A, Berardi R, Body mass index and hormone receptor status influence recurrence risk in HER-2 positive early breast cancer patients, Clinical Breast Cancer (2019), doi:
    This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
    Title page
    Body mass index and hormone receptor status influence recurrence risk in HER-2 positive early breast cancer patients